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For diabetes management, the dose can be increased at 4-week intervals to a maximum of 15 mg weekly

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This narrative review summarizes the therapeutic effects of different incretin hormones and presents future prospects in the treatment of T2DM and obesity

Intermittent or reduced-dose strategies lack robust clinical trial support and may result in partial benefit loss

Serious but rare risks include pancreatitis with tirzepatide and lactic acidosis with metformin, particularly in patients with kidney impairment

He didn't want to take the risk even though his 300 to 400 patients on it have been calling nonstop to complain about losing access