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Description
Lilly's triple agonist, retatrutide, delivered powerful weight loss in pivotal Phase 3 obesity trial

Key physiological impacts include: Increased work of breathing due to chest wall mass Reduced lung compliance and diaphragmatic excursion Decreased functional residual capacity and expiratory reserve volume Higher metabolic demands requiring increased respiratory effort Obesity is also strongly associated with obstructive sleep apnoea (OSA), a condition where breathing repeatedly stops during sleep, further compromising respiratory function and contributing to daytime breathlessness

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The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying
