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Gastrointestinal side effects like nausea, vomiting, and constipationcommon with GLP-1 medicationscan be especially problematic during adolescence, potentially interfering with school attendance, social functioning, and nutritional status

Glucose-dependent Insulinotropic Peptide Glucose-dependent Insulinotropic Peptide (GIP) is a 42-amino acid peptide hormone produced by K cells located primarily in the proximal small intestine (44)

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Potential contributors to variation in weight-loss response to liraglutide

Slowing stomach emptying

Clinical trials have shown that Wegovy treatment resulted in a statistically significant reduction in body weight compared to placebo after 68 weeks