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Across these studies, the notion of food aversion and nausea through GLP-1 signaling has been implied, but there lacks sufficient evidence to support this claim [56]

Switching from Semaglutide to Tirzepatide: People switch if they feel semaglutide isnt effective enough or want the added benefit of GIP activation

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Semaglutide may be an option if you struggle with hunger, have difficulty keeping weight off, or havent achieved meaningful results with diet and exercise alone

J Med Chem 58(18):73707380

A Mayo Clinic study published in the Lancet Obstetrics found that women using tirzepatide alongside HRT achieved 17 percent weight loss compared to 14 percent with tirzepatide alone