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Several randomized, controlled clinical trials have shown that this drug is effective in reducing pain and fatigue and improving sleep quality (increased slow-wave sleep duration and decreased night-time awakenings)
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Both have been FDA-approved for managing type 2 diabetes and have shown significant success in weight loss treatments

In preliminary findings from preclinical studies, concurrent therapy with GLP-1RAs and SGLT-2is may change intestinal microbial biology in distinctive or synergistic ways

Dehydration is particularly concerning because it can impair kidney function, which then affects metformin clearance

Malik VS, Willet WC, Hu FB

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