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This causes: Increased membrane permeability Tubular cell injury and necrosis GFR Result: Acute tubular necrosislike picture 2 Renal vasoconstriction (hemodynamic effect) Amphotericin B causes afferent arteriolar vasoconstriction

Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes

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Treatment requires specialist prescribing, regular monitoring for adverse effects including pancreatitis, and integration with lifestyle modifications

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