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Incretins are gut-derived peptide hormones, primarily GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), secreted after nutrient intake to enhance glucose-dependent insulin release from pancreatic cells
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Rybelsus also had low rates of hypoglycemia in patients with type 2 diabetes mellitus
Recent clinical trials, including a new head-to-head study, have further corroborated these findings, confirming that Tirzepatide leads to more significant reductions in body mass on average than Semaglutide
