endogenous glp-1 Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action Current Insights, Advantages and Challenges

The final rule is not yet published as of this article's date

Second, GLP-1R activation enhances neurovascular coupling function, improves cerebral blood flow and repairs BBB integrity, blocking the penetration of peripheral inflammatory factors into the center (Wong et al., 2024)

Patients should plan for the program to end on December 31, 2027, unless extended

Note for women using oral contraceptives : Tirzepatide may reduce the absorption of oral contraceptives, particularly during initiation and dose increases

Candeias E, Sebastio I, Cardoso S, Carvalho C, Santos MS, Oliveira CR, et al

The primary outcome was new onset hypersomnolence with secondary outcomes including parasomnia, narcolepsy/cataplexy, disturbed sleep, restless legs syndrome, iron deficiency, and Parkinsonism