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It gradually loses potency

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This can increase sodium and water excretion and may slightly reduce circulating blood volume

[PMC free article] [PubMed] [Google Scholar] 73.Galli J.A., Sawaya R.A., Friedenberg F.K

Over 72 weeks patients lost on average 21% of their starting weight

Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia