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A study in Diabetes found that when GLP-1 receptors are triggered in colon tissue, they can change how the lining of the colon grows and develops
To manage this: Drink small, frequent sips of water throughout the day rather than large amounts at once If nausea makes plain water unappealing, try ginger tea or water with a small amount of lemon Contact your healthcare team if you cant keep fluids down for more than 24 hours Watch for signs of dehydration: reduced urine output, dark urine, dizziness, or dry mouth If you have advanced CKD and your nephrologist has asked you to restrict fluids, follow their guidance rather than the general advice above

Foods high in fiber, fat, or sugar can slow gastric emptying and compound semaglutide's effects on your stomach, increasing nausea

If you are unable to digest fats, there could be several causes

It can take anywhere from 48 weeks for a full transition
