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However, among 13 711 matched pairs comparing GLP1RA and DPP4 inhibitor users, GLP1RA initiation was associated with a significantly reduced risk of depression (HR 0.90, 95% CI: 0.820.98)

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GIPR is primarily expressed in pancreatic -cells, adipose tissue, the small intestine, and the central nervous system playing a key role in energy metabolism and nutrient homeostasis

BMI 27 kg/m with a weight-related condition: Patients with a BMI of 27 or higher (overweight) may qualify if they also have a weight-related condition such as type 2 diabetes, hypertension, high cholesterol, or sleep apnea

J Clin Invest (1995) 96(6):255568