quitting glp 1 cold turkey Wegovy: why half the people taking the weight loss drug stop within a year – and what happens when they do Safely stopping GLP-1 medication

RCT SCALE Study - Liraglutide vs Placebo for Weight Loss in Overweight Nondiabetic Adults, NEJM (2015) [PubMed abstract] The SCALE study enrolled 3731 overweight adults who did not have diabetes Main inclusion criteria BMI 30

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Starting at the lowest dose and increasing the dose gradually over time may help to minimize side effects

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Retatrutide engages GLP-1R, GIPR, and GCGR with differential but meaningful potency at each site, producing a composite pharmacodynamic signal not achievable with single or dual agonists

But the way they are marketed raises uncomfortable questions about the future of health care