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Risk of bias was assessed using an adapted Quality Assessment Tool for In Vitro Studies (QUIN) tool

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Lifestyle modification and nutrition-based approaches are regarded as the cornerstone strategies for treating pediatric obesity

In terms of switching, 22.9% of the GLP-1 receptor agonist users and 2.1% of the SGLT2 inhibitor users switched between drugs within the same drug class

Results We identified 3999 US adults weighted to an estimated population size of 93.0 million [M] (38% of US adults) who fit STEP 1 eligibility criteria

Additional significant interactions were observed for all-cause death in females and in people with a history of smoking, alcohol use, heart failure, chronic kidney disease, or cholelithiasis