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4:e005325 [PMC free article: PMC4275683] [PubMed: 25526792] 331

Prioritize flexible components that allow fast pivots

Individuals with a history of depression, anxiety disorders, bipolar disorder, or previous suicidal thoughts or attempts should be carefully evaluated before initiating therapy

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Even if GLP-1 and GIP secretion are present in these scenarios, both hormones usually have decreased effectiveness

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