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The GLP-1 analogs, semaglutide and liraglutide, delay the progression of atherosclerosis by regulating inflammatory pathways in low-density lipoprotein receptor-deficient (LDLr -/- ) and apolipoprotein E-deficient (ApoE -/- ) mice [16]

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Based on this observation, DPP-4 inhibitors may be less effective in high-fat-diet-fed Gcg RA Null and Gcg RA VilCre mice that depend on GIP to mediate DPP-4 inhibitory effects
On the upside: Early research suggests they may improve brain insulin signaling, lower inflammation, protect blood vessels, and even encourage new neuron growth all potentially protective against Alzheimers

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Effect of Subcutaneous Tirzepatide vs Placebo added to titrated insulin glargine on Glycemic Control in patients with type 2 diabetes: the SURPASS-5 Randomized Clinical Trial
