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While paraxanthine delivers most of caffeine's beneficial effects with a relatively short half-life of 3.1 hours, the other two metabolites are more problematic

Regulatory submission dependent on Phase 3 results

This medication should only be taken once per week

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Hormonal Connection: Insulin surges and crashes can lead to a craving for fast carbs

Your body has completely lost its tolerance to the medication, and jumping to a higher dose will cause severe gastrointestinal symptoms including nausea, vomiting, and potential dehydration