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The combined actions of these two agents increase Bax expression, inhibit Bcl-2 levels, and downregulate the phosphorylation of ERK and Akt, collectively suppressing prostate cancer progression and promoting apoptosis
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Placebo subtracted weight loss at the end of the study was 13.6% (5 mg), 19% (10mg), and 20.1% (15mg), and over 50% of the participants treated with 10 or 15 mg doses achieved greater than 20% weight loss

2015 Feb;14(2):207-18

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