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Primary Uses in Diabetes and Obesity Management Originally developed for the treatment of type 2 diabetes, GLP-1 agonists have proven effective in promoting weight loss, making them valuable in obesity management as well

One of the largest and most robust studies is the SURMOUNT-4 trial

Due to the extensive amount of interest in these drugs, GLP-1 co-agonists are also being developed around the world to treat T2DM or obesity, and some show greater effects than Ozempic, Saxenda, or Wegovy [30,31]

GLP-1 receptor agonists, particularly semaglutide and tirzepatide, have fundamentally changed how patients and prescribers approach metabolic health and weight management

So for T2D, the goal is to give the patient the minimum dose they need to achieve the desired glycemic management and minimize side effects

Quick Answer: GLP-1 receptor agonists produce significant reductions in abdominal fat and waist circumference as part of generalized weight loss, though they do not selectively target belly fat