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Cmax was not affected

Serum leptin and insulin concentrations were measured by ELISA, and gene and protein expression levels were analyzed by qRT-PCR and Western blot, respectively

The number on the scale may be acting like the 'canary in the coal mine.' It may be telling us about swallowing issues, loss of smell, gastrointestinal dysfunction, frailty, muscle loss, medication interactions or changes in cognition long before these problems become obvious