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Common Side Effects Trulicity common side effects: Nausea (12-21%) Diarrhea (8-12%) Vomiting (6-12%) Abdominal pain (7-10%) Decreased appetite (5-9%) Indigestion (5-8%) Ozempic common side effects: Nausea (15-20%) Vomiting (5-10%) Diarrhea (8-10%) Abdominal pain (6-8%) Constipation (3-5%) Decreased appetite (intended effect) Side Effect Comparison Table The rates are broadly similar, with individual variation determining which medication a particular patient tolerates better