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Oral semaglutide reduced body weight in people with T2D on insulin with/without metformin (PIONEER 8) [29]

The added glucagon activation appears responsible for retatrutide's higher reported weight loss in trials

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Orforglipron showed similar gastrointestinal side effects as other GLP-1 drugs, with the most common being diarrhea, nausea, indigestion, and constipation
Accordingly icv administration of insulin antibodies increased food intake and body weight (53)
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Recently, a federal judge in Louisiana largely denied Novo Nordisks motion to dismiss the lawsuit, particularly the claims concerning inadequate warnings about the risk of gastroparesis, allowing these cases to proceed
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