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The trial randomized participants across three retatrutide doses (4 mg, 9 mg, 12 mg) versus placebo, all administered once weekly by subcutaneous injection

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Glucagon-Like Peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

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[1] [3] These mechanisms improve glycaemic control but can also contribute to symptoms such as light-headedness through several pathways

Data availability The EHR database used in this study were obtained from TriNetX ( Abbreviations GLP-1RAs: Glucagon-like peptide-1 receptor agonists T2DM: Type 2 diabetes mellitus EHRs: Electronic health records SGLT2: Sodium-glucose cotransporter-2 DPP-4: Dipeptidyl peptidase-4 HR: Hazard ratios CI: Confidence intervals References Alfaris N, Waldrop S, Johnson V, Boaventura B, Kendrick K, Stanford FC (2024) GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review