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Experimental observations also show delayed gastric emptying consistent with GLP-1 receptor signaling, although this effect may diminish over extended observation periods in some research models

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PlexusDx patients typically see initial results within 48 weeks, with continued weight loss over 36 months of consistent treatment

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Food aversions are common, particularly to previously enjoyed foods

Lifestyle integration Strength training and education about long-term healthy behaviours are key to avoiding the common yo-yo effect research shows that, even with GLP-1 medications, most participants regain weight within 12 months if lifestyle change is not consolidated