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Once lymph enters the initial lymphatics, some of the key factors that determine efficient lymph transport along the collecting lymphatic vasculature are 1) efficient contractility, 2) the ability of collecting lymphatics to properly vasodilate as part of the contraction cycle, 3) competent intraluminal valves, and 4) a relative low permeability that ensures lymph remains within the lymphatic vasculature

( 3 ) In the SURMOUNT-4 trial, patients with obesity receiving tirzepatide had a mean 25.3% body weight loss over 88 weeks

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Data reported in this post hoc analysis are from the tirzepatide 15 mg and MTD treatment arms compared to placebo

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