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Description
The novel incretin agonist, named I-M-150847, promotes robust glucose-stimulated insulin exocytosis in cultured pancreatic beta cells

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Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.

Explore how GLP-1 treatments impact dopamine and the brains reward system, shaping cravings, eating behavior, and daily enjoyment.

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Researchers are examining whether drugs currently approved to treat obesity and type 2 diabetes could be useful for a wider range of health challenges.
