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You feel like your body can no longer naturally regulate your appetite

Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet
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There are other examples of drugs that were developed later but ultimately became more successful, Phipps noted, such as with statins and TNF-alpha inhibitors

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Some doctors prescribe it off-label for weight loss, but thats not its official use
