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this effect is explained by the delay of gastric emptying observed under tirzepatide administration (61)

Arch Emerg Med Crit Care

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Possible side effects include: Nausea, diarrhea, vomiting, constipation, mild to moderate abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, belching, hypoglycemia, flatulence, gastroenteritis, loss of lean muscle mass and gastroesophageal reflux disease

GIPs effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(330)NH2