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Nausea and gastrointestinal symptoms are the most frequently reported side effects, affecting up to 40% of patients initiating therapy

TABLE 3

They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies

, Derksen, D

This early adoption is reshaping the treatment journey for many

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Graaf C., Donnelly D., Wootten D., Lau J., Sexton P.M., Miller L.J., Ahn J.M., Liao J., Fletcher M.M., Yang D., et al