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doi: 10.1016/S1474-4422(20)30173-3 [DOI] [PubMed] [Google Scholar] 169.Detka J, Gombik K

Pharmacokinetics: Bioavailability: ~90% Half-life: ~2430 hours Metabolism: Minimal hepatic metabolism Excretion: Mainly renal Adverse Effects: Headache Nausea Abdominal pain Diarrhea Interesting Fact: Unlike older prokinetic agents (like cisapride), prucalopride has high receptor selectivity, reducing the risk of cardiac arrhythmias a major safety improvement

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Rossing P, Baeres FMM, Bakris G et al

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