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doi: 10.1016/j.physbeh.2019.03.026 [DOI] [PMC free article] [PubMed] [Google Scholar] 161.Egecioglu E, Engel JA, Jerlhag E

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The Clinical Application of GLP-1RAs and GLP-1/GIP Dual Receptor Agonists Based on Pharmacological Mechanisms: A Review

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In pancreatic -cells, in enteroendocrine L-cells throughout the gut, and in the caudal portion of the nucleus tractus solitary of the brainstem, the preproglucagon (PPG) is processed by the prohormone convertase 1/3 into GLP-1 and other peptides (Larsen et al., 1997