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Glucagon receptor activation increases thermogenesis (heat production from burning calories), enhances fat oxidation (the breakdown of stored fat for energy), and boosts resting metabolic rate

Findings, while suggestive, cannot be generalized without further research, as individual patient factors, concomitant medications, and clinical context may influence outcomes [41]

Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow

Participants taking the highest weekly dose of retatrutide lost, on average, 28% of their body weight, about 70 pounds, with nearly half losing 30% or more

Cardiovasc Diabetol 19:79
