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doi: 10.2337/dc20-1622

While semaglutide does not require strict dose adjustments for mild-to-moderate renal impairment, PlexusDx requests recent lab workincluding creatinine, eGFR, and liver enzymesto verify that your organ function can safely handle the medication

For example, using incorrect injection sites or techniques could cause discomfort, bruising, or other unwanted skin reactions

Normally: Angiotensin I (ACE) Angiotensin II Angiotensin II causes: Vasoconstriction Aldosterone release Increased blood pressure After Captopril: Angiotensin II Vasoconstriction Aldosterone Blood pressure Bradykinin (causes cough) Indications Hypertension Heart failure Post-myocardial infarction Diabetic nephropathy Left ventricular dysfunction Dosage Hypertension: Start: 12.525 mg 23 times daily Maintenance: 2550 mg 23 times daily Heart Failure: Start low (6.25 mg TDS) Titrate gradually Dose adjustment needed in renal impairment

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UK Evidence Review Ozempic (semaglutide) is a GLP-1 receptor agonist licensed in the UK exclusively for treating type 2 diabetes mellitus in adults