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Some people use lower doses during breaks rather than complete discontinuation, but this strategy lacks clinical validation

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Human studies have demonstrated that for those with obesity, prediabetes, or early-stage T2D, liraglutide slows a decline of memory function independent of weight reduction

Cardiovascular Evidence# LEADER Trial (Liraglutide)# The LEADER trial (Marso et al., NEJM 2016) enrolled 9,340 patients with T2D and high CV risk, followed for median 3.8 years: 3-point MACE: HR 0.87 (95% CI 0.78-0.97, p=0.01) -- 13% reduction Cardiovascular death: HR 0.78 (22% reduction) All-cause mortality: HR 0.85 (15% reduction) Liraglutide was the first GLP-1 agonist to demonstrate cardiovascular benefit, and LEADER remains a landmark trial in the class

Registered pharmacist Lucy Broughton discusses antidepressant withdrawal, including the symptoms experienced, how to distinguish it from relapse, why it happens and how to prevent it

For RF, treat the temple area with reduced intensity (skin is thin here and vasculature is dense)