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The most effective prebiotics for semaglutide users include partially hydrolyzed guar gum (PHGG), which improves stool consistency without excessive gas production, acacia fiber, which is gentle on sensitive stomachs and feeds Bifidobacterium species, and resistant starch from cooled potatoes, green bananas, or supplements, which selectively promotes butyrate-producing bacteria
It was FDA approved in 2023 and has shown impressive results so far
doi: 10.1530/ETJ-24-0079 80 HuangGLinYZhuG

Stick to bananas, rice, applesauce, peeled and grated apple, and toast (BRAT diet)

GLP-1 medications are often used in patients with chronic kidney disease, and caution is warranted
A lyophilized vial in the same conditions will be fine because the degradation reactions that heat accelerates require water to proceed