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10.1002/cne.10454 [DOI] [PubMed] [Google Scholar] Klonoff, D

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It was not clear how a drug that primarily affects glucose metabolism might directly impact the occurrence of cardiovascular events

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In proglucagon gene ( Gcg ) knockout mice, the GLP-1 receptor antagonist, exendin 9-39, led to impaired glucose tolerance when Gcg was reactivated in the pancreas, but not when intestinal Gcg was reactivated (115)

GLP-1 drug therapy helps in multiple ways: Improves insulin production when blood sugar is high Reduces the release of glucagon, a hormone that increases blood sugar Slows down gastric emptying, making you feel full for longer Reduces appetite, leading to fewer calorie intakes These combined effects make GLP-1 agonists powerful tools for diabetes weight control