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Brain inflammation is believed to impair nerve function and increase BBB permeability during major depressive disorder

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doi:10.1016/S0140-6736(18)31924-X 12

Esketamine exhibits greater sympathomimetic and serotonergic activity than arketamine (Mion & Villevieille, 2013
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Therefore, the results should be interpreted with caution, particularly for suspected ADRs based on a limited number of reports
