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Realistic Expectations and When to Reassess Your Treatment Plan If you are not approaching 10% weight loss by week 1620 at adequate dose, or if weight loss plateaus below your target, your provider may adjust dose, add complementary interventions, or evaluate underlying factors such as medication adherence, diet quality, physical activity, sleep, or uncontrolled metabolic conditions

This is usually the first sign of a problem

Ranasinghe C, et al

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Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study