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Those in the trial that did experience negative side effects did so at the same rate and consistency as those previously reported for injectable GLP-1 drugs and Eli Lilly said it "was consistent." The drugmaker said the most commonly reported negative side effects were mild to moderate gastrointestinal-related symptoms, such as nausea, constipation, indigestion, diarrhea and vomiting

doi: 10.3389/fphar.2021.706908 42

Due to their patents, only these companies are legally allowed to mass-produce and market the original versions of these drugs, subject to strict oversight by the FDA to ensure safety, efficacy, and proper manufacturing practices

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It has been possible to map the incretin function in humans in some detail owing to the availability of receptor antagonists for both hormones, namely exendin 9-39 for the GLP-1 receptor and the amidated GIP fragment GIP 3-30 amide for the GIP receptor [2]