small molecule glp-1 agonist Oral Small-Molecule Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies Oral GLP-1-Based Therapeutics in the
Description
Nefrologia 2023;43:399412

248 , G118123 (1985)

[11] Yale School of Medicine

10.1016/S0140-6736(19)31149-3 9

Other Safety Considerations Several additional safety topics are relevant to the clinical use of orforglipron: Gallbladder events: GLP-1 receptor agonists have been associated with increased rates of cholelithiasis and cholecystitis, likely mediated by rapid weight loss altering bile composition and gallbladder motility

Adv Chronic Kidney Dis
