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Subsequently, LEADER and SUSTAIN-6 were reported, which investigated respectively liraglutide and semaglutide vs

The gastrointestinal effects dominate, particularly during the dose escalation phase
J Biol Chem 2002
Since GLP-1 medications naturally slow gastric emptying, eating slowly and chewing your food well can align with the medications effects, making digestion smoother

Labeling and instructions can differ from the approved product, which makes dose comparisons less straightforward
NICE guidance emphasises combining Wegovy with dietary modification and a 500 kcal daily deficit for optimal weight management outcomes
