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Participants with T2D at high risk for cardiovascular (CV) events ( n = 9,340) were randomised 1:1 to receive either liraglutide (1.8 mg daily

Janus kinase (JAK) inhibitors represent newer targeted synthetic DMARDs with demonstrated efficacy, though they carry boxed warnings regarding serious infections, malignancy, major adverse cardiovascular events, and thrombosis

Our findings highlight the need for policy interventions to address those factors and could inform discussions between healthcare providers and patients around challenges with obesity pharmacotherapy