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A patient with genetic variants linked to higher hunger drive may benefit from remaining at the lower end of the calorie range (1,2001,400) or combining semaglutide with a complementary approach, while someone with lower baseline appetite might thrive at 1,6001,800 calories while still losing weight steadily

For patients seeking deeper personalization, the PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month) maps 14 metabolic pathways and 49 peptides to identify how your genetics influence GLP-1 and GIP receptor sensitivity

Some newer treatments, like Mounjaro, combine GIP with GLP-1 activity

Am J Nephrol 2017;46:462472 [DOI] [PMC free article] [PubMed] [Google Scholar] 7

A recent clinical study found that people who exercised while taking medications like Ozempic were more likely to keep weight off and regained less weight if they eventually stopped the medication, compared to those who didnt exercise

Or if you are losing weight too rapidly (more than 1-2% of body weight per week consistently), which increases the risk of gallstones, muscle loss, and metabolic disruption