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When GLP-1 is secreted from L-cells through the TGR5 agonist, it stimulates GLP-1R in enterochromaffin cells and induces serotonin or 5-hydroxytryptamine (5-HT) secretion from these cells

[4] Due to the high demand for GLP-1 drugs in the U.S

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However, a similar level of reduction in low-density lipoprotein (LDL) cholesterol and apolipoprotein B was seen with both tirzepatide and dulaglutide [18]

In the vascular system, oxidative stress in diabetes activates ROS-mediated Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascades, promoting autophagy in endothelial cells while downregulating HDAC6 expression, which impairs cell migration and adhesion

For example, instead of 2 mg once weekly, you would inject 1 mg twice weekly