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Expert Rev Pharmacoecon Outcomes Res 21:221233

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Characterization of collagenase, other metallo-proteinases and an inhibitor (Timp) produced by human synovium and cartilage in culture
Thyroid cancer, particularly medullary thyroid carcinoma (MTC), has been closely monitored given the rodent study findings
Between 3044 mL/min/1.73 m, metformin can be continued at reduced doses (maximum 1,000 mg daily) but should not be newly initiated

[1] It is used as a diluent to dissolve or dilute medications for intravenous (IV), intramuscular (IM), or subcutaneous (SQ) injection according to the instructions of the specific drug being prepared
