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The researchers optimized the potency ratio between the three receptors and used a protraction strategy that allows for once-weekly dosing, then tested the drugs in diet-induced obese mice

found that GLP-1 can reduce oxidative stress in BV2 microglia by inhibiting the accumulation of intracellular ROS and release of nitric oxide (NO), as well as by increasing the expression of the antioxidant glutathione peroxidase 1 (GPx1) and superoxide dismutase 1 (SOD1) (184)

To avoid redundancies across similar articles, this paper sought to instead further summarize and highlight specific key similarities and differences among important and overlapping theme categories between previously published works on the topic

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