reduce basal insulin when starting glp-1 receptor agonist Adjusting Your Pump a Medication Current Insights, Advantages and Challenges

Kalogirou MS, Patoulias D, Haidich AB, Akriviadis E, Sinakos E

Anti-rebound strategies should be integrated into the clinical pathway, including intensified lifestyle maintenance and, where appropriate, sequential metformin to maintain metabolic stability

As the native GLP-1 has a short half-life, GLP-1 analogues have been produced to prolong effects and many of them could cross blood-brain barriers (BBB) such as Liraglutide (LG), lixisenatide, and exendin-4

Finally, given that GLP-1 agonists have become mainstream and popular in the media, it may just be that reporting of adverse events is higher relative to other drugs [26]

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Early-life stress and HPA axis trigger recurrent adulthood depression