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Meanwhile, Wegovy is FDA-approved for chronic weight management in adults with obesity

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The Wegovy FDA label mentions acute kidney injury and worsening of chronic renal failure in patients taking GLP-1 receptor agonists, even sometimes requiring hemodialysis

Many endpoints are tested with borderline p-values

[1] These are surrogate endpoints, not clinical events, and the history of cardiovascular medicine is filled with cautionary tales about therapies that improved surrogate markers without improving outcomes

However, it should be used under medical supervision to assess suitability and monitor for potential side effects
