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5.9 Risk of Seizures with Abrupt Withdrawal of Phentermine and Topiramate Extended-Release Capsules Abrupt withdrawal of topiramate has been associated with seizures in individuals without a history of seizures or epilepsy

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Blocking GLP-1 receptors with exendin-9,39 did not affect caloric intake in post-bariatric surgery patients, but it did reduce caloric intake in their weight-matched control group [125]

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Weight plateaus are more commonly due to metabolic adaptation and decreased energy expenditure as body weight declines

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