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In the cardiac magnetic resonance (CMR) sub-study of the SUMMIT trial, in comparison with the placebo, the treatment of obesity-related HFpEF with tirzepatide can lead to a reduction in LV mass and pericardiac adipose tissue

Weight gain itself is associated with metabolic conditions that may increase thyroid disease risk, meaning semaglutide-assisted weight loss could theoretically reduce long-term thyroid burden rather than increase it

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Along with all your other possible mechanisms: gut microbiome, direct immune effects, CNS effects

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