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Speak with Your Prescribing Clinician Your first step should be to talk to the healthcare provider who prescribed the GLP-1 medication

By late 2025, an estimated 3040 million Americans (~1012.5% of adults) were taking GLP-1 drugs ( [1] ) ( [2] )

This study further strengthens the existing evidence in favor of GLP-1 based therapies in decreasing total cholesterol, LDL-cholesterol and triglycerides

Key natural GLP-1 alternatives include: Berberine Supports glucose metabolism and gut-hormone balance, often described as a natural GLP-1 activator

Beyond glycemic control, the pleiotropic actions of GLP-1 on various organs and metabolic pathways are emphasized, underscoring its potential utility in addressing cardiovascular, renal, and obesity-related complications

It also points to the need for better strategies to make these treatments more accessible and available to those who need them. Prior to this research, a small study of 106 postmenopausal women published in 2024 in the medical journal Menopause found that those who were on both MHT and the GLP-1 drug semaglutide had lost about 16 percent of their total body weight after a year, compared to 12 percent for women on a GLP-1 alone